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) use. We report two sufferers with no prior heritage of neurological disorder that seasoned their initial generalized tonic–clonic seizure after using tobacco Spice. The mechanism powering the feasible proconvulsant impact of synthetic cannabinoids isn't identified, but it may be because of their consequences within the cannabinoid receptor CB1.

The respiratory depressant results of opioids contain carbon dioxide retention and secondary elevation of cerebrospinal fluid force, and could be markedly exaggerated during the existence of head injuries, other intracranial lesions or a pre-present increase in intracranial tension.Physical dependence is manifested by withdrawal indications after a